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KMID : 0380020200350030228
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Korean Journal of Biotechnology and Bioengineering
2020 Volume.35 No. 3 p.228 ~ p.234
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Inhibitory Effects of Dryopteris erythrosora Extract on Tyrosinase Activity and Melanin Production in B16F10 Melanoma Cells
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Koo Yeon-Su
Park Tae-Jin
Sim Ji-Han
Kim Min-Seon
Kim Seung-Young
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Abstract
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In this study, we investigated the effect of Dryopteris erythrosora extract on anti-oxidation and tyrosinase activity and melanin production as natural products of functional cosmetics. Melanin contents of B16F10 melanoma cells were decreased by 10%, 21%, and 24% in a dose-dependent manner, upon Dryopteris erythrosora extract treatment at 50, 100, and 200 μg/mL, respectively. Concentration of 200 μg/mL of Dryopteris erythrosora extract especially induced greater decreases in tyrosinase activity. As a result, Dryopteris erythrosora extract showed a 70% reduction in concentration of 200 μg/mL. Dryopteris erythrosora extract suppressed expression of tyrosinase, tyrosinase related protein-1 (TRP-1), tyrosinase related protein-2 (TRP-2), and microphthalmia-associated transcription factor (MITF) in B16F10 melanoma cells. Concentration of 200 μg/mL of Dryopteris erythrosora extract especially induced greater decreases in tyosidase activity and melanogenic enzyme protein expressions. This results indicate that Dryopteris erythrosora extract inhibits melanin synthesis and tyrosinase activity, and Dryopteris erythrosora extract may be an ideal candidate as a skin whitening agent.
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KEYWORD
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Dryopteris erythrosora, anti-oxidation, tyrosinase activity, whitening agent, microphthalmia-associated transcription factor
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